身体质量指数对人类中风后第一天内免疫反应的影响
Johanna Ruhnau1, Christin Heuer2, Carl Witt2
1Department of Neurology, University Medicine Greifswald, F.-Sauerbruch-Str, 17475, Greifswald, Germany. johanna.ruhnau@uni-greifswald.de.
Neurological research and practice
|August 16, 2023
概括
在中风患者中,较高的身体质量指数 (BMI) 与增加的前炎性免疫反应相关. 这表明肥胖可能通过改变免疫功能对中风结果产生负面影响.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 代谢研究的研究.
背景情况:
- 脑卒中病理生理学涉及免疫学变化,增加感染易感性.
- 肥胖与慢性免疫激活和脂肪组织功能改变有关.
- 了解不同BMI的中风患者的免疫反应至关重要.
研究的目的:
- 为了研究免疫功能 (单细胞,粒细胞,细胞因子) 与体重指数 (BMI) 和中风后体重变化相关.
- 评估肥胖如何影响缺血性中风后的免疫特征.
主要方法:
- 在中风和对照患者中使用MRI评估体重和脂肪状态 (肝脏,内脏).
- 在外周血液和血清中量化白细胞子群,细胞因子,化学因子和基因.
- 采用多重回归分析来将BMI与免疫细胞种群相关联.
主要成果:
- 卒中患者在入院后经历了最初的体重和脂肪损失.
- 更高的BMI与IL-6相反相关,但与促炎性细胞因子 (eotaxin,IFN-β,IFN-γ,TNF-α) 有正相关.
- 增加的BMI与减少的抗炎单细胞 (CD14+CD16+) 和特定颗粒细胞以及增加的促炎颗粒细胞相关.
结论:
- 在BMI和中风后的亲炎性免疫反应之间存在正相关性.
- 肥胖可能会通过促进促炎性免疫环境而加剧中风.
- 研究结果表明,在中风患者中,肥胖,免疫失调和临床结果之间存在联系.
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