对治疗甲基胺使用障碍潜在药物的兴趣和偏好进行定性研究
Karla D Wagner1, Charles Marks2, Phillip Fiuty3
1School of Public Health, University of Nevada, 1664 N. Virginia St. MC 0274, Reno, NV, 89557, USA. karlawagner@unr.edu.
Addiction science & clinical practice
|August 16, 2023
概括
患有甲基胺使用障碍 (MUD) 的人对药物感兴趣,这些药物提供了与甲基胺相似的功能益处,同时减少了危害. 治疗偏好侧重于改善功能和福祉,而不仅仅是禁欲.
科学领域:
- 药物中毒药物 药物中毒药物
- 心理药理学 心理药理学
- 公共卫生 公共卫生
背景情况:
- 甲基胺使用障碍 (MUD) 带来了重大的公共卫生挑战.
- 了解患者的观点对于开发有效的MUD治疗至关重要.
研究的目的:
- 评估治疗MUD的潜在药物的可接受性和偏好.
- 探索甲基胺使用的感知好处和缺点如何影响治疗偏好.
主要方法:
- 对20名报告使用甲基胺的个人进行了定性采访.
- 采访探讨了物质使用模式,甲基胺的感知好处/缺点,以及对MUD药物的兴趣.
- 分析采用了感应性主题方法.
主要成果:
- 大多数参与者对潜在的MUD药物表达了热情.
- 对药物效应的偏好是由甲基胺的功能益处 (例如,能量,情绪增强) 塑造的.
- 参与者希望药物可以模仿兴奋剂效果,同时减轻诸如精神病和戒断等不良结果.
结论:
- 患有MUD的个体对药物治疗表现出强烈的兴趣.
- 治疗偏好与甲基胺的功能作用有关,突出了需要支持福祉和功能的药物.
- 未来的MUD治疗研究应该考虑禁欲之外的结果,专注于功能改善.
更多相关视频
09:29Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
2.2K
10:17High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
9.7K
相关概念视频
01:15Drug Abuse and Addiction: Pharmacological Phenomena
512
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
512
01:17Drug Dependence
1.0K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.0K
01:24Substance Use Disorders Affecting Sleep
196
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
196
01:28Drug Therapy
68
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
68
01:17Phase II Reactions: Methylation Reactions
229
Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
229
01:24CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
234
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
234