随机试验在实施科学中的作用是什么?
Robbie Foy1, Noah M Ivers2, Jeremy M Grimshaw3
1Leeds Institute of Health Sciences, University of Leeds, Leeds, UK. r.foy@leeds.ac.uk.
Trials
|August 16, 2023
概括
随机试验对于实施科学至关重要,尽管存在争论. 改进试验设计和流程可以提高它们对基于证据的实践的相关性和及时性.
科学领域:
- 实施科学 实施科学
- 医疗保健服务研究 医疗服务研究
- 基于证据的实践.
背景情况:
- 实施科学对于弥合全球证据和实践之间的差距至关重要.
- 评估实施策略的有效性是一个关键的研究目标.
- 随机试验被认为是确定有效性的黄金标准,但未得到充分利用.
研究的目的:
- 为解决关于随机试验在实施科学中的作用的持续辩论.
- 为了回应实施科学中随机试验的批评.
- 提出方法来提高随机试验的及时性和相关性.
主要方法:
- 在实施科学中讨论随机试验的批评.
- 突出创新试验设计的机会.
- 建议将试验嵌入大规模改进计划中,并使用常规数据.
- 建议加强伙伴关系和简化道德/治理程序.
主要成果:
- 随机试验面临关于"现实世界"证据,复杂干预和上下文因素的批评.
- 创新的设计,与改进计划的整合以及常规数据可以提高试验的相关性.
- 与政策制定者的合作和简化审批可以加速试验的进行.
结论:
- 随机试验设计不应该为评估实施策略而过早放弃.
- 提高进行随机试验的条件对于强大的实施科学至关重要.
- 政策制定者和研究人员必须合作,以优化试验方法.
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