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脑部MRI间部体积偏差甚至在对多发性硬化症的协调多主体研究中也存在

Kelly A Clark^1,2, Carly M O'Donnell^1,2, Mark A Elliott³

¹Penn Statistics in Imaging and Visualization Endeavor, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Journal of neuroimaging : official journal of the American Society of Neuroimaging

|August 16, 2023

概括

多中心核磁共振成像研究显示,在多发性硬化症 (MS) 患者的大脑体积测量中,部位和扫描器偏差显著. 先进的统计方法对于在多中心研究中减轻这些偏见至关重要.

科学领域:

神经成像研究研究的神经成像.
医学成像分析分析医学成像分析
多发性硬化症 (MS) 研究研究

背景情况:

使用各种MRI扫描仪的多中心研究是常见的.
扫描仪和现场变化在基于图像的测量中引入了偏差.
评估这些偏见对于可靠的多中心研究至关重要.

研究的目的:

为了评估不同MRI扫描仪和地点的大脑体积的偏差.
评估扫描仪和部位差异对MS患者基于图像测量的影响.
调查统计建模在缓解这些偏差方面的有效性.

主要方法:

在四个地点使用西门子和飞利浦3T扫描仪从11名多发性硬化志愿者那里获得了MRI数据.
执行了自动化病变检测和大脑/脑垂体体积测量,以及手动划分.
使用随机效应和非参数建模来分析站内和站内差异.

主要成果:

非参数建模揭示了超过50%的体积变化被解释的位置,混合扫描器数据增加到75%以上.
在大多数大脑体积估计 (P < .05) 中发现了显著的内部和内部区别.
一个遮光器件影响了胸膜体积测量,显示了受影响和不受影响的扫描之间的显著差异.

结论:

脑体积差异在MRI扫描仪中仍然存在,即使使用了协调的协议.
差异组件建模不足以解释这些差异.
统计学创新显示,有望减少多中心多发性硬化症研究中的偏见.

关键词:

这就是为什么MRI是MRI.多发性硬化症多发性硬化症白质病变 - 白质病变的病变

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