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急性心肌梗塞的炎症:好的,坏的和丑的

Michael A Matter^1,2, Francesco Paneni^1,2, Peter Libby^3,4

¹Department of Cardiology, University Heart Center, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

European heart journal

|August 16, 2023

概括

治疗急性心肌梗塞 (AMI) 后的炎症需要一个平衡的方法. 针对过度炎症的早期治疗,同时保持有益的修复机制是改善心血管结果的关键.

科学领域:

心血管医学心血管医学
炎症研究炎症研究
翻译心脏病学翻译心脏病学

背景情况:

促炎途径在冠状动脉疾病病理生理学中至关重要.
兴趣正在转向治疗急性心肌梗塞 (AMI) 后的急性炎症.
以前针对残留炎症风险 (RIR) 的试验显示了益处,但也显示了诸如受损宿主防御等风险.

研究的目的:

审查和综合针对IMI后炎症的证据.
为AMI后的急性阶段提出一个优化的抗炎策略.
要区分有益的修复/防御和有害的炎症.

主要方法:

对AMI后抗炎疗法的实验和临床证据的分析.
针对早期过度炎症 (例如IL-1,IL-6通路) 的小规模试验的审查.
综合从过去的研究中吸取的经验教训,为新的治疗方法提供信息.

主要成果:

针对早期炎症,特别是IL-1和IL-6的试验显示出有前途.
需要一个细微的策略来解决"坏" (RIR) 和"丑" (早期爆发),同时省略"好" (修复/防御).
建议的策略包括患者选择 (高炎症负担),早期治疗启动 (≤12h),向药物和逐渐减少的治疗方案.

结论:

建议针对急性AMI后炎症采用优化,精确向的抗炎方法.
这一策略旨在平衡控制有害炎症的作用,同时保护重要的宿主防御和修复机制.
拟议的方法需要通过严格的临床试验进行验证.

关键词:

剧烈的心肌梗塞急性心肌梗塞抗炎疗法是一种抗炎疗法.炎症炎症是一种炎症.结果结果的结果.

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