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深层瘤的超声驱动的压电催化免疫激活

Anbang Wu^1,2, Lingdong Jiang^2,3, Chao Xia²

¹Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|August 17, 2023

概括

这项研究引入了用于深度瘤治疗的超声驱动压电催化. 它使用SnS纳米片产生气和减少乳酸,激活抗瘤免疫力并实现完整的瘤根除.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
在瘤学瘤学.

背景情况:

瘤异质性阻碍了药物透,并限制了固体瘤的治疗疗效.
分子 (H2) 和超声波 (US) 提供高组织透性和免疫调节作用.
乳酸 (LA) 积累有助于免疫抑制瘤微环境.

研究的目的:

开发一种新的策略,用于使用超声驱动的压电催化瘤免疫激活来高效治疗深层瘤.
为了研究压电催化生成和乳酸剥夺对增强癌症治疗的综合效应.
创建一个超声响应的压电材料,用于局部治疗效果.

主要方法:

开发超声响应的压电SnS纳米片 (SSN) 用于向治疗.
在 ортотоп性肝癌模型中进行SSN的内注射.
超声波 (US) 应用以触发局部H2生产和LA剥夺.
评估免疫细胞激活 (CD8+ T 细胞,调节性 T 细胞) 和PD-L1表达.

主要成果:

SSN使美国触发的本地H2生产和LA剥夺在深层瘤中成为可能.
通过降低PD-L1表达的调节,生成的H2释放了效应体CD8+ T细胞.
通过抑制调节性T细胞,LA剥夺激活了CD8+T细胞.
该策略在患有肝癌的小鼠中实现了完全瘤根除和100%的存活率.

结论:

超声驱动的压电催化瘤免疫激活是深度瘤治疗的安全有效策略.
H2生成和LA剥夺的组合协同增强了抗瘤免疫力.
SnS纳米片显示出作为超声波触发癌症治疗的治疗剂的前景.

关键词:

疗法是一种疗法.免疫激活系统的激活纳米医药是一种纳米医药.压电催化剂是一种催化剂.瘤免疫疗法免疫疗法

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