作为卵巢毒性物质:一篇综述
Jitender Kumar Bhardwaj1, Prerna Bikal1, Som Nath Sachdeva2
1Reproductive Physiology Laboratory, Department of Zoology, Kurukshetra University, Kurukshetra, Haryana, India.
Journal of applied toxicology : JAT
|August 17, 2023
概括
(Cd) 暴露会通过氧化应激和卵泡亡来损害卵巢,从而损害女性生育能力. 了解这些影响是开发生殖健康干预措施的关键.
科学领域:
- 环境毒理学环境毒理学
- 生殖生物学 生殖生物学
- 卵巢毒理学 卵巢毒理学
背景情况:
- (Cd) 是一种有毒的重金属,在人类中没有已知的生物作用.
- 由于其长半衰期和低分泌率,cd生物累积,导致器官损伤,特别是在卵巢中.
- 由于Cd的卵巢毒性与氧化应激,卵泡缩,荷尔蒙干扰和卵细胞发育受损有关.
研究的目的:
- 审查目前关于对卵巢过程的影响的研究.
- 阐明Cd诱导的卵巢毒性背后的机制,包括氧化应激和亡.
- 总结潜在的治疗策略,以减轻Cd诱导的卵巢损伤.
主要方法:
- 对调查卵巢组织中的毒性研究的文献综述.
- 对Cd诱导的氧化应激,卵泡亡和类固醇生成抑制研究的分析.
- 收集有关原性影响和补救方法的数据.
主要成果:
- 会在卵巢组织中诱导显著的氧化应激和亡.
- 暴露于CD会破坏正常的卵泡发育和类固醇激素合成.
- 毒性与不良的生殖结果有关,包括不孕.
结论:
- 对女性生殖健康和生育能力构成重大威胁.
- 了解CD的卵巢毒性机制对于开发有效的干预措施至关重要.
- 抗氧化剂和药用草药在治疗引起的卵巢损伤方面表现有前途.
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