LncRNA AWPPH在多种癌症中的新兴作用:一项综述研究
Mohsen Sheykhhasan1, Fateme Dermani2, Nematollah Gheibi3
1Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Current molecular medicine
|August 17, 2023
概括
长非编码RNA WAPPH (lncRNA WAPPH) 在各种人类癌症中充当瘤基因. 这篇评论强调了 lncRNA WAPPH 的重点.
科学领域:
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
- 在瘤学瘤学.
背景情况:
- 长非编码RNAs (lncRNAs) 是基因表达在表观遗传,转录,后转录和转化水平的关键调节者.
- 在人类恶性瘤和患者预后中,LncRNAs起着至关重要的作用.
- 位于染色体2q13上的lncRNA WAPPH是一种新发现的lncRNA,在癌症中具有重大影响.
研究的目的:
- 综合审查和功能性讨论lncRNA WAPPH在各种人类癌症中的作用.
- 阐明lncRNA WAPPH在瘤发生和癌症进展中的致癌功能.
- 探索lncRNA WAPPH在固体和血液癌症的生物过程中的参与.
主要方法:
- 文献综述和对关于lncRNA WAPPH.现有研究研究的分析.
- 对lncRNA WAPPH在癌症发展中的作用的功能性评估.
- 检查lncRNA WAPPH在各种癌症类型中的参与,包括乳腺癌,胃癌,结直肠癌,卵巢癌,膀癌和白血病.
主要成果:
- 在广泛的人类恶性瘤中,lncRNA WAPPH经常受到放松管制.
- lncRNA WAPPH作为一种瘤基因,促进瘤发生和癌症的发展.
- lncRNA WAPPH涉及到各种生物过程,这些过程对固体瘤和血液恶性瘤的癌症进展至关重要.
结论:
- lncRNA WAPPH是人类癌症中的一个重要瘤基因.
- 在许多癌症类型中,lncRNA WAPPH表现出不受管制的表达.
- lncRNA WAPPH具有作为人类恶性瘤的诊断生物标志物和治疗点的潜力.
相关概念视频
lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
Non-Canonical Wnt Signaling Pathways
7.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K
Canonical Wnt Signaling Pathway
8.8K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.8K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K


