在儿科松芽细胞瘤中BCOR表达
Joanna Trubicka1, Maria Łastowska1, Agnieszka Karkucińska-Więckowska1
1Department of Pathology, The Children's Memorial Health Institute, Warsaw, Poland.
Folia neuropathologica
|August 17, 2023
概括
BCOR蛋白在松芽细胞瘤中表达,这是一个罕见的儿科脑瘤. 这一发现可能有助于区分松芽细胞瘤与松果区域的其他高等级瘤.
科学领域:
- 神经瘤学神经瘤学
- 分子病理学分子病理学
- 儿科瘤学 儿科瘤学
背景情况:
- BCOR基因的改变定义了一个特定的中枢神经系统瘤实体 (HGNET BCOR).
- 在其他高度儿科脑瘤中,BCOR表达通常不会被发现.
- 在罕见的质瘤中,EP300-BCOR融合会导致BCOR免疫阳性.
研究的目的:
- 在松芽细胞瘤和生殖细胞瘤中研究BCOR表达.
- 评估BCOR作为中枢神经系统瘤的诊断标记物的潜力.
- 为了探索BCOR参与儿科松果区域瘤.
主要方法:
- 对BCORRNA表达的NanoString nCounter系统分析.
- 对BCOR蛋白的免疫组织学检测.
- 对66种高级儿科瘤的分析,包括松芽细胞瘤,生殖细胞瘤和ATRTs.
主要成果:
- 在所有研究的松芽细胞瘤中检测到BCORRNA和蛋白质表达.
- 在胚芽瘤和非典型的甲状腺形瘤 (ATRTs) 中,BCOR表达不存在.
- 在松芽细胞瘤中没有发现BCOR内部合重复或融合事件.
结论:
- BCOR表达是松芽细胞瘤的一个特征.
- 免疫组织学检测BCOR可以区分松芽细胞瘤与其他高等级桃区域瘤.
- BCOR作为芽细胞瘤的潜在诊断标志物.
更多相关视频
07:53Author Spotlight: Using the Chick Embryo Brain as a Model for In Vivo and Ex Vivo Analyses of Human Glioblastoma Cell Behavior
Published on: May 26, 2023
3.7K
03:13Author Spotlight: A Single-Entry Point Endoscopic Intraventricular Approach for Third Ventriculostomy and Pineal Biopsy
Published on: June 28, 2024
699
相关概念视频
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...