新辅助化疗对乳腺癌患者手术内核心温度的影响:一项回顾性队列研究
Daniel D Kim1,2, Sarah M DeSnyder3, Patrick M Dougherty4
1Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
BJA open
|August 17, 2023
概括
乳腺癌患者的新辅助化疗与较低的手术内温度和增加的血管压缩剂使用有关. 神经病变在全身麻醉期间加剧了这些影响.
科学领域:
- 在瘤学瘤学.
- 麻醉学 麻醉学
- 心血管生理学心血管生理学
背景情况:
- 众所周知,化疗剂会导致神经病变和自主功能障碍.
- 新辅助化疗对手术期间体温的影响尚不清楚.
研究的目的:
- 研究新辅助化疗对乳腺癌患者手术内核心温度的影响.
- 分析新辅助化疗,手术内温度和麻醉管理之间的关联.
主要方法:
- 对1764名经过乳腺切除术的乳腺癌患者的回顾性分析 (2016年4月至2020年7月).
- 倾向性得分匹配,将接受新辅助化疗的患者与没有接受化疗的患者进行比较.
- 在全身麻醉期间分析手术内核心温度模式,血管压缩剂的使用和心率.
主要成果:
- 新辅助化疗组表现出较低的手术内平原温度 (高达0.4°C的差异,P=0.005).
- 在两组中都观察到类似的热量再分配和回暖模式.
- 化疗组的神经病变与增加的血管压缩剂使用和更高的心率相关.
结论:
- 新辅助化疗与乳腺癌患者的手术内核心温度降低有关.
- 在全身麻醉期间增加血管压缩剂的使用和心率与新辅助化疗有关.
- 神经病变在接受新辅助化疗的患者中加剧了这些麻醉相关的并发症.
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