在LEEP前后:分析女性泌尿器官微环境及其与性功能障碍的关联
Olivia Giovannetti1, Diane Tomalty1, Leah Velikonja1
1Department of Biomedical and Molecular Science, Queen's University, Kingston K7L3N6, Canada.
Sexual medicine
|August 17, 2023
概括
宫发育不良症的循环电外科切除手术 (LEEP) 可以改变女性泌尿器官 (FUT) 微生物群. 虽然LEEP经常恢复健康的微生物群,但持续的变化可能与性功能障碍 (SD) 症状相关.
科学领域:
- 妇科瘤学 妇科瘤学
- 微生物组研究 微生物组研究
- 女人的性健康 女性的性健康
背景情况:
- 通过循环电外科切除程序 (LEEP) 治疗宫发育不良 (CD) 已知会影响女性泌尿器官 (FUT) 微生物群.
- FUT微生物群的变化与性功能障碍 (SD) 有关,但与LEEP的具体关系尚未详细说明.
研究的目的:
- 为了描述FUT微生物群在CD的LEEP之后发生的变化.
- 研究这些微生物群变化与SD的发展或持久性之间的潜在关联.
主要方法:
- 招募接受LEEP进行CD的女性参与者.
- 收集尿液,阴道和子宫样本用于LEEP前后的16SrRNA测序.
- 使用女性性功能指数 (FSFI) 和人口调查评估性功能.
主要成果:
- LEEP导致FUT微生物群的整体物种丰富性下降.
- 在LEEP后的宫,尿道和阴道部位中观察到微生物组成的显著变化,普遍趋势是增加*Lactobacillus* spp.
- 虽然FSFI评分整体没有显著变化,但一些参与者显示LEEP后FSFI评分与特定炎症或保护性细菌的变化之间存在关联.
结论:
- 一般来说,LEEP促进了FUT微生物群失生症的减少,使微环境恢复到更健康的状态.
- 存在变化,一些人经历了持续的失生症和与FSFI分数升高的潜在联系.
- 未来的研究应该专注于监测和恢复LEEP后的FUT微环境,以潜在地减轻SD症状.
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