术前炎症对活着的日子和手术后在家中的影响
David Kunkel1, Margaret Parker1, Cameron Casey1
1Department of Anesthesiology, University of Wisconsin, Madison, WI, USA.
BJA open
|August 17, 2023
概括
通过IL-8和IL-10测量的外科手术期间炎症,预测老年手术患者活着和在家的日数减少 (DAH90). 然而,当被纳入模型时,妄想变得是显著的预测因素,表明炎症.
科学领域:
- 老年医学 老年医学
- 外科手术的结果
- 炎症生物标志物 炎症生物标志物
背景情况:
- 外科手术期间的炎症与 Delirium 等并发症有关.
- 痴呆症对术后结果产生负面影响,特别是活着和在家的日子 (DAH90).
研究的目的:
- 为了调查外科手术期间炎症和DAH90.0.之间的关联.
- 为了确定炎症是否独立地预测DAH90在调整为妄想后.
主要方法:
- 对134名65岁以上接受重大非内外科手术的患者进行前性队列研究.
- 测量了术后妄和IL-8和IL-10的血水平.
- 使用量子位回归分析DAH90.
主要成果:
- 在不考虑痴呆症之前,术后IL-8和IL-10的增加与DAH90的减少有关.
- 经过对妄和认知功能进行调整后,IL-8和IL-10都不是DAH90的显著预测因素.
- 痴呆症成为DAH90.0的重要预测因素.
结论:
- 外科手术期间的炎症预测了DAH90,但当考虑妄想时,它的重要性会减少.
- 妄,而不是炎症,是这个队列中DAH90的关键预测因素.
- 针对外科手术期间的炎症可能是减少妄想并改善患者治疗结果的策略.
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