旋转手套肌损伤的发展中的微RNA表达变化
Giuseppe Francesco Papalia1,2, Edoardo Franceschetti1,2, Giancarlo Giurazza1,2
1Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Roma, Italy.
JSES reviews, reports, and techniques
|August 17, 2023
概括
微RNAs (miRNAs) 在旋转 (RC) 肌损伤中起着关键作用,影响肌肉退化和纤维化. 了解这些miRNA变化可能会导致肩部疼痛的新诊断和治疗策略.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 整形外科手术 整形外科手术
背景情况:
- 旋转手套 (RC) 肌损伤导致严重的肩膀疼痛和残疾,每年在美国需要超过25万次手术.
- 微RNA (miRNA) 是基因表达的关键调节者,影响组织发育和转录后的功能.
研究的目的:
- 审查和识别RC病理患者的miRNA表达变化.
- 评估miRNAs作为RC疾病新型诊断和治疗工具的潜力.
主要方法:
- 在PubMed,Medline,Scopus和Cochrane Central数据库中进行了全面的文献搜索.
- 包括11项英语研究,调查miRNA在RC损伤诊断,病理生理学和治疗中的作用.
主要成果:
- 多个miRNA被确定为RC病原体,炎症和肌肉脂肪退化中的关键调节者.
- 这些miRNAs影响肌体生成,炎症性细胞因子产生,金属蛋白酶表达,肌肉适应,脂肪生成,纤维生成和细胞外矩阵合成.
结论:
- 在病理性旋转手套肌病变中,miRNA表达发生变化.
- 对miRNA基因机制的进一步研究对于开发RC肌病的未来诊断和临床应用至关重要.
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