1型糖尿病儿童C-值的变化 - 一项为期三年的研究
Carmen Nicoleta Novac1, Doina-Andrada Mihai2,3, Anca Andreea Boboc1,2
1"M. S. Curie" Emergency Clinical Hospital for Children, Bucharest, Romania.
Maedica
|August 17, 2023
概括
患有1型糖尿病 (T1DM) 的年幼儿童经历了更快的C-下降. 较高的初始C-水平和在诊断时缺乏糖尿病酸症 (DKA) 预测了在三年内更好的剩余胰岛素分泌.
科学领域:
- 内分泌学 在内分泌学.
- 儿童糖尿病研究 儿童糖尿病研究
- 代谢疾病监测 代谢疾病监测
背景情况:
- C- (CP) 是评估胰岛素治疗1型糖尿病 (T1DM) 患者内源性胰岛素产生的关键生物标志物.
- 监测CP水平对于了解疾病进展和残留β细胞功能至关重要.
研究的目的:
- 在T1DM诊断后的最初三年内,跟踪儿童的血清C水平.
- 确定影响儿科T1DM患者C-分泌率下降的因素.
- 为了将诊断时的临床参数与长期残留胰岛素分泌相关联.
主要方法:
- 一项追溯纵向队列研究,涉及215名患有T1DM的儿童和青少年.
- 在诊断时和每年三年分析空腹血清C值.
- 评估包括糖尿病酸性 (DKA) 严重程度,HbA1c,家族病史,性别和发病时的传染病等因素.
主要成果:
- 初始C水平较低 (<0.6 ng/mL) 的患者在诊断时更年轻,并患有DKA和并发感染的比例更高.
- 一个T1DM/T2DM的家族史与C-的更快的下降有关.
- 在诊断时的C-水平和HbA1c之间没有发现相关性或患者的性别.
结论:
- 较高的初始C度预测了在诊断后三年保存的剩余胰岛素分泌 (> 0.6 ng/mL).
- 诊断时年轻的年龄与C-分泌的更快下降有关.
- 严重的DKA和发病时的传染病表明快速降低C的风险更高.
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