全球趋势和胃肠道微生物群和毒性的热点,基于参考资料
Jiajia Duan1, Chuanxin Liu2, Xiaoyang Bai3
1Department of Clinical Laboratory, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Frontiers in microbiology
|August 17, 2023
概括
关于胃肠道微生物组和毒性的研究正在增长,中国和美国处于领先地位. 关键的发现显示了向微塑料等环境污染物的转变,并突出了肠-大脑轴.
科学领域:
- 环境科学 环境科学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
- 微生物组研究 微生物组研究
背景情况:
- 毒性在公共卫生,环境科学和药理学方面仍然是一个重大问题.
- 人们越来越认识到胃肠道微生物组在毒性和人类健康中的作用.
- 这项研究提供了关于胃肠道微生物组和毒性的全球研究的文献分析.
研究的目的:
- 评估胃肠道微生物组和毒性研究的全球科学成果和趋势.
- 确定关键的研究重点和新兴主题.
- 绘制国际合作和有影响力的研究实体的地图.
主要方法:
- 从1980年到2022年,对2,140个英语出版物的图书统计分析.
- 已经使用了 Web of Science 核心集合,Biblioshiny,R,CiteSpace 和 VOSviewer.
- 分析了出版物数量,引用指标,关键词,作者网络和国家/机构合作.
主要成果:
- 研究产出的显著增加,以中国和美国为首.
- 研究重点从制药转向环境污染物,特别是微塑料.
- 确定了关键机制 (氧化应激,新陈代谢,炎症,亡) 和目标器官 (胃肠道,肝脏,大脑).
- 强调了肠-大脑轴的日益重要以及斑马鱼模型的使用.
结论:
- 这项研究为当前的胃肠道微生物组和毒性研究领域提供了宝贵的见解.
- 未来的研究可能会探索微生物组的修改,以减轻毒性.
- 结果为相关领域的研究人员提供了全面的概述.
相关概念视频
01:29Microorganisms in Medicine and Therapeutics
54
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
54
01:29Bacterial Flora of the Large Intestine
512
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
512
01:50What is Monogastric Digestion?
71.5K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.5K
02:11The Roles of Bacteria and Fungi in Plant Nutrition
36.1K
Plants have the impressive ability to create their own food through photosynthesis. However, plants often require assistance from organisms in the soil to acquire the nutrients they need to function correctly. Both bacteria and fungi have evolved symbiotic relationships with plants that help the species to thrive in a wide variety of environments.
36.1K