人类认知和社会特征的进化和功能障碍:一个转录调节视角
1Department of Biology, Lund University, Lund, Sweden.
Evolutionary human sciences
|August 17, 2023
概括
转录调节基因的功能丧失将人类认知进化与精神障碍联系起来. 这些基因的发生不足解释了适应性特征和疾病持续性.
科学领域:
- 进化生物学是进化的生物学.
- 发育遗传学的发展遗传学.
- 神经科学是一个神经科学.
背景情况:
- 人类大脑和面演变赋予了独特的认知和社会技能.
- 这些进化变化也使人类易患精神障碍,破坏这些特征.
研究的目的:
- 探索连接人类认知进化和精神障碍持久性的发育遗传基础.
- 提出转录调节基因功能丧失作为一个关键环节.
主要方法:
- 审查转录调节基因中哈普洛缺陷的证据.
- 分析部分基因功能丧失在人类特征进化中的作用.
- 检查功能丧失变体的进化选择压力.
主要成果:
- 转录调节基因,往往是平分不够的,对功能丧失突变敏感.
- 这些基因的部分功能丧失可能有助于人类大脑和面进化 (自我化).
- 对功能丧失变异的选择解释了精神疾病通过突变选择漂移的持续性.
结论:
- 转录调节基因的功能丧失是人类认知/社交和精神障碍病因学的适应性进化之间的关键联系.
- 这个框架将进化变化与精神病的遗传基础相协调.
- 提出可测试的预测来验证这些假设.
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