基因与运动对超重/肥胖儿童大脑健康的相互作用:ActiveBrains随机对照试验
Abel Plaza-Florido1,2, Irene Esteban-Cornejo1,3,4, Jose Mora-Gonzalez1
1Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Journal of applied physiology (Bethesda, Md. : 1985)
|August 17, 2023
概括
超重/肥胖儿童和有利的遗传特征显示,在运动干预后,认知灵活性得到了更大的改善. 这表明遗传学影响了儿科大脑健康中的运动反应.
科学领域:
- 儿科运动科学 儿科运动科学
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
背景情况:
- 运动反应的个体间变异性会影响大脑健康结果.
- 遗传因素与成人运动反应有关,但在儿童中尚未探索.
- 了解遗传影响对于个性化儿科干预至关重要.
研究的目的:
- 研究遗传分数和运动对超重/肥胖儿童大脑健康的相互作用.
- 为了确定遗传特征是否会改变运动引起的认知和学术成果的变化.
- 探索特定多态 (BDNF,CREB1,NTRK2,COMT,APOE) 在运动反应中的作用.
主要方法:
- 101名超重/肥胖儿童 (10.0±1.5岁) 被随机分配到20周的运动干预或对照组.
- 评估了认知灵活性,学术技能和海马体积.
- 六个与大脑健康相关的基因多态化被基因定型,以创建一个遗传分数.
主要成果:
- 与对照组相比,运动组的认知灵活性和学术技能明显提高,但仅在具有"有利"遗传特征的儿童中.
- 个体反应分析显示,62%的遗传优势儿童在运动中表现出有意义的认知灵活性改善,而对照组的这一比例为25%.
- 遗传学对运动反应的影响对于认知灵活性来说是最一致和最重要的.
结论:
- 良好的遗传特征可以提高对超重/肥胖儿童进行认知灵活性干预的反应能力.
- 遗传背景在调节儿科人口中运动诱导的大脑健康益处方面发挥着重要作用.
- 这些发现支持基于遗传特征的个性化运动处方的潜力.
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