对辅助生殖技术的一种新方法,在患有内膜异位症的女性中使用益生菌来治疗不孕症
Oksana V Bakun1, Oksana A Andriiets1, Maryna D Hresko1
1BUKOVINIAN STATE MEDICAL UNIVERSITY, CHERNIVTSI, UKRAINE.
概括
益生菌的使用显著降低了NLRP3炎症酶表达在接受辅助生殖技术的子宫内膜异位症相关不孕症妇女. 这表明益生菌是一种可行的ART的准备策略.
科学领域:
- 生殖医学 生殖医学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 与子宫内膜异位症相关的不孕症与NLRP3炎症酶活性升高有关.
- 辅助生殖技术 (ART) 对于治疗不孕症至关重要.
- 益生菌在调节子宫内膜异位症炎症途径中的作用需要进一步研究.
研究的目的:
- 在患有子宫内膜异位症相关不孕症的女性中研究NLRP3炎症酶表达.
- 评估益生菌作为这些患者ART预备治疗的疗效.
主要方法:
- 一项涉及30名不育妇女的研究 (20名患有子宫内膜异位症,10名患有输卵管不育症).
- 在ART.前一个月内,子宫内膜异位症组接受了基于Lactobacillus的益生菌.
- 在益生菌治疗前后使用RT-PCR分析NLRP3炎症酶基因表达.
主要成果:
- 在接受益生菌治疗前与治疗后 (0.70) 相比,内膜异位症患者的NLRP3炎症酶表达显著更高 (24.43).
- 对照组的基线NLRP3炎症酶表达为0.54.
- 益生菌干预导致NLRP3炎症酶表达减少了34倍以上.
结论:
- 益生菌补充剂有效地降低了与子宫内膜异位症相关的不孕症妇女中NLRP3炎症酶水平的升高.
- 这种益生菌方法显示出作为ART制剂的辅助疗法的前景.
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