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Updated: Jul 19, 2025

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery
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加尔纳克结合siRNAs的药理动力学和药理动力学

Guohua An1

  • 1Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USA.

Journal of clinical pharmacology
|August 17, 2023
PubMed
概括

小干扰RNAs (siRNAs) 是一个有前途的新药类. 本综述详细介绍了用于治疗开发的N-甲胺结合siRNAs的药理动力学/药理动力学 (PK/PD).

关键词:
在GalNAc结合的siRNAs中.siRNAs 的临床药理学他们会给你一个Givosiran.这里是inclisiran的意思.这就是Lumasiran.如果RNA PK/PDsiRNA药量测量模型的制造在Vutrisiran中使用Vutrisiran.

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