在L.I.L.里面, rhamnosus CNCM I-3690人类小肠微生物群的生存,适应和影响
Edoardo Zaccaria1,2, Tim Klaassen2,3, Annick M E Alleleyn3
1Host Microbe Interactomics Group, Wageningen University & Research, Wageningen, The Netherlands.
Gut microbes
|August 17, 2023
概括
乳酸菌 (Lacticaseibacillus rhamnosus) 在人类小肠中存活下来,适应其新陈代谢以影响肠道活动. 这项研究揭示了对潜在益生菌效应至关重要的功能调整.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 代谢工程是代谢工程.
背景情况:
- 发酵食品将细菌引入胃肠道.
- 关于微生物在小肠中的生存和适应的知识有限.
研究的目的:
- 为了研究 Lacticaseibacillus rhamnosus CNCM I-3690 在人类小肠中的生存和适应.
- 分析L. rhamnosus在肠道过境期间的代谢反应.
- 评估L. rhamnosus对小肠微生物群活动的影响.
主要方法:
- 殖民地形成单位 (CFU) 计数和定量PCR (qPCR) 在阴道排水中.
- 在现场和体外对L. rhamnosus进行转录基因组分析.
- 进行比较的转录组分析.
主要成果:
- 在小肠中,L. rhamnosus的生存率很高.
- 观察到显著的代谢适应,包括碳水化合物代谢,表面蛋白质表达和翻译的变化.
- L. rhamnosus改变了小肠微生物群的整体活动概况,特别是碳水化合物代谢途径.
- 肠-大脑代谢模块的丰富 (内醇降解,谷氨酸合成II) 被注意到.
结论:
- L. rhamnosus 在人类小肠中具有显著的生存能力.
- 在L. rhamnosus的现场功能调整对其益生菌潜力至关重要.
- 这种菌株调节了小肠生态系统的活动,但没有大大改变其组成.
关键词:
拉姆诺斯乌斯 (L. rhamnosusus) 是一个有趣的动物.人类 人类 人类 人类 人类 人类 人类在位基因表达的基因表达.转录元组 (metatranscriptome) 是一个转录元组.益生菌的命运 益生菌的命运小肠小肠的小肠的小肠.更多相关视频
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