用康复期血治疗的COVID-19患者
Lise Sofie Haug Nissen-Meyer1, Magnhild Eide Macpherson2, Linda Gail Skeie2
1Seksjon for blodgivning, Avdeling for immunologi og transfusjonsmedisin, Oslo universitetssykehus.
概括
在挪威,COVID-19康复性血治疗一般耐受良好. 接受这种治疗的免疫功能低下患者的死亡率与免疫能力较强的个体相比可能更低.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 在挪威的NORPLASMA项目中,给予了COVID-19康复期血.
- 最初的治疗是针对重症患者,后来仅限于重症免疫受损患者.
研究的目的:
- 在接受COVID-19康复血的患者中描述临床特征,并发病率和死亡率.
- 评估康复期血在不同患者群体中的安全性和潜在疗效.
主要方法:
- 一项观察性研究包括从2020年4月到2022年3月的79名患者.
- 关于免疫状况,并发症和结果的数据从患者记录中收集.
- 在15个医疗保健机构中注射了193个康复期血单位.
主要成果:
- 患者的中位数年龄为65岁,整体住院死亡率为39% (79人中31人).
- 在59名免疫功能低下患者中,有20人死亡,而20名免疫能力低下患者中有11人死亡.
- 治疗耐受性良好,只有两名患者出现轻度过敏皮肤反应.
结论:
- COVID-19康复性血似乎安全用于患者治疗.
- 免疫功能低下的患者可能会从康复性血治疗中获得生存益处.
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