了解剪切薄化粘弹性滴在狭窄微通道中的变形和破裂倾向
Niraj Kr Prasad1, Siddhartha Sankar Ghosh2, Amaresh Dalal1
1Department of Mechanical Engineering, Indian Institute of Technology Guwahati, 781039 Guwahati, India.
Langmuir : the ACS journal of surfaces and colloids
|August 17, 2023
概括
这项研究使用粘弹性滴滴模型模拟细胞和药物载体变形. 计算模拟揭示了道限制和流体特性如何影响微通道中的下降行为.
科学领域:
- 流体动力学 流体动力学
- 生物物理学的生物物理.
- 材料科学是一种材料科学.
背景情况:
- 微流体中的细胞和药物载体行为对于药物输送至关重要.
- 粘弹性滴滴模型对于理解复杂的流体动力学是必不可少的.
- 微毛细管流对粒子变形和分解提出了独特的挑战.
研究的目的:
- 为了研究剪切稀释有限可伸缩非线性弹性-彼得林 (FENE-P) 滴的变形和破裂.
- 分析各种参数对狭窄微通道下降行为的影响.
- 为了确定启动滴断的关键毛细血管数.
主要方法:
- 一个双相粘弹性滴滴牛顿矩阵系统的计算模拟.
- 使用开源解决方案Basilisk进行模拟.
- 系统地改变了诸如通道限制,Deborah数和毛细血管数等参数.
主要成果:
- 滴变形和断裂受到道限制,Deborah数,溶剂粘度比,粘度比和毛细血管数量的显著影响.
- 确定了控制狭窄微通道下降行为的关键参数.
- 提供了关于滴裂启动关键毛细血管数量的见解.
结论:
- 计算机模拟为药物载体在狭窄的微毛细血管中的变形和分解模式提供了宝贵的见解.
- 这些发现可以指导纳米载体的设计,以提供有针对性的药物.
- 了解这些动态对于优化药物释放机制至关重要.
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