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肝脏疾病中肝脏内皮细胞的内皮病变

Reiichiro Kondo¹, Yasuko Iwakiri², Masayoshi Kage³

¹Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.

Pathology international

|August 17, 2023

概括

肝脏侧腔内皮细胞 (LSEC) 损伤,称为炎性内皮病,导致肝炎C和COVID-19等疾病的肝损伤. 恢复LSEC功能为肝脏疾病提供了潜在的治疗策略.

科学领域:

肝病学肝病学是一种肝病学.
血管生物学血管生物学
免疫学免疫学免疫学

背景情况:

肝脏的鼻状细胞由肝脏的鼻状内皮细胞 (LSECs) 覆盖,这对于维持肝脏平衡至关重要.
在肝病中,血液动力学变化可能导致LSEC损伤,这种情况称为炎症性内皮质病.
内皮细胞通常调节白细胞静止,并抑制血液凝结;在炎症期间,这种功能会丧失.

研究的目的:

讨论在各种肝脏疾病中LSECs的损伤.
突出炎症内皮病在慢性肝炎C和COVID-19等疾病中的作用.
探索针对LSEC功能的潜在治疗策略.

主要方法:

关于肝脏疾病中LSEC功能和损伤的现有文献的综述.
讨论 LSEC 功能障碍背后的机制,包括 IL-6 转信号等炎症媒介.
分析LSEC内皮病的后果,例如白细胞和血小板的积累.

主要成果:

在LSEC中,炎症性内皮质病有助于慢性型肝炎中血小板的积累,可能会影响切除术的结果.
在COVID-19中,由IL-6转信号诱导的LSEC内皮病促进中性粒细胞和血小板聚合,导致肝损伤.
IL-6跨信号调节LSEC中的粘附分子 (ICAM-1,P-选择蛋白,E-选择蛋白) 和化学激素 (CXCL1,CXCL2),促进细胞积累.

结论:

在各种肝脏疾病中,LSEC损伤和炎性内皮质变异是导致肝损伤的重要因素.
恢复LSEC功能是改善肝损伤的关键目标.
预防内皮质变异症为治疗肝病提供了一个有希望的治疗途径.

关键词:

这就是SARS-CoV-2病毒.慢性肝炎是一种慢性肝炎.介质蛋白-6 介质蛋白-6 是一种肝脏的阴侧内皮细胞内皮细胞.血栓形成的原因是血栓形成.

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