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Sai Ma¹, Zhonghua Wang¹, Chao Li¹

¹Department of Stomatology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075000, China.

|August 17, 2023

概括

与癌胚抗原相关的细胞粘附分子1 (CEACAM1) 在口腔癌中显著下调,与患者预后较差相关. 这表明CEACAM1可能作为口腔状细胞癌的潜在生物标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
基因组学就是基因组学.

背景情况:

口腔癌,主要是状细胞癌,是由口腔粘膜的转变引起的.
癌胚抗原相关细胞粘附分子1 (CEACAM1) 在口腔癌病原发生中的作用在很大程度上仍未确定.

研究的目的:

研究CEACAM1在口腔癌中的表达特征和潜在作用.
确定关键的分子通路和与口腔癌发展相关的基因.

主要方法:

对基因表达数据集 (GSE23558,GSE25099) 的分析,以确定差异表达基因 (DEG).
权重基因共同表达网络分析 (WGCNA) 和蛋白质-蛋白质相互作用 (PPI) 网络构建.
进行了基因本体学 (GO),基因和基因组的京都百科全书 (KEGG) 和西方涂抹 (WB) 分析.

主要成果:

确定了1269个DEGs,富含PI3K-Akt和TGF-β信号传递等与癌症相关的途径.
CEACAM1被确定为PPI网络中的关键基因,并被发现在口腔癌组织中显著下调.
在口腔癌样本中,西部涂抹证实了较低的CEACAM1表达,在CEACAM1敲击后进一步减少.

结论:

在口腔癌中,CEACAM1的表达较低,这表明与疾病进展存在潜在的逆相关性.
降低CEACAM1水平与口腔癌患者的预后不佳有关,突出其作为预后生物标志物的潜力.

关键词:

在CEACAM1中.生物信息学是一种生物信息学.分子点是分子点.口腔癌是口腔癌的一种疾病.

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