在2型糖尿病患者中,肥胖主导了对心脏结构和动脉硬的早期影响
Layla A Abushamat1,2, Daniel Enge1,3,4, Takashi Fujiwara5
1Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Journal of hypertension
|August 17, 2023
概括
2型糖尿病 (T2D) 和肥胖导致心血管疾病 (CVD) 的风险. 这项研究发现T2D和肥胖不活跃个体的亚临床动脉硬化和心脏重塑,表明这些因素促进心血管疾病并发症.
科学领域:
- 心脏病学 心脏病学
- 代谢障碍 代谢障碍 代谢障碍
- 医疗成像医学成像
背景情况:
- 2型糖尿病 (T2D) 和肥胖是全球主要的健康挑战,显著增加心血管疾病 (CVD) 的风险.
- 亚临床心脏和血管功能障碍是心血管疾病的早期指标,特别是在T2D和肥胖症患者中.
研究的目的:
- 调查标准和新型心脏磁共振成像 (MRI) 参数.
- 在身体不活跃的个体中检测亚临床心脏和中枢血管功能障碍,有或没有T2D.
主要方法:
- 身体不活跃的绝经前妇女和没有并发症的T2D (n=22) 和没有T2D但超重/肥胖 (CWO,n=34) 的男性与参考对照队列 (RC,n=20) 相比.
- 使用MRI评估左心室 (LV) 结构和功能,以及大动脉硬度.
- 通过度和区域PWV测量全球动脉脉冲波速度 (PWV),使用2D相对比MRI和4D流MRI.
主要成果:
- 全球动脉PWV在CWO和T2D组之间没有差异.
- 2D PC-MRI PWV在上升性大动脉中在T2D组比CWO (P <0.01) 更高.
- 与RC相比,胸前动脉中的4D流PWV在CWO (P < 0.01) 和T2D (P < 0.001) 中较高. 在CWO和T2D组与RC相比,LV体积和心脏输出减少.
结论:
- 与对照组相比,在不活跃的超重/肥胖和T2D患者中存在亚临床动脉硬化和心脏重塑.
- 肥胖和身体不活动似乎是不复杂的T2D中初始心血管疾病并发症的关键决定因素.
- 需要进一步的研究来阐明导致心血管疾病并发症的确切机制,并确定治疗点.
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