在社区的队列中微量营养素缺乏和新发性心房动:来自PREVEND的数据
Ali A Al-Mubarak1, Niels Grote Beverborg1, Victor Zwartkruis1
1Department of Cardiology, University of Groningen, University Medical Center Groningen, UMCG Post-Zone AB43, PO Box 30.001, 9700 RB, Groningen, The Netherlands.
概括
缺乏与非吸烟者的新发性心房动 (AFib) 有关. 需要进一步的研究来证实因果关系,并探索补充在风险人群的干预措施.
科学领域:
- 心脏病学 心脏病学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 心血管疾病,包括心力衰竭 (HF),与营养不良有关.
- 和铁缺乏与HF患者的预后较差有关.
- 微量营养素缺乏在心房 (AFib) 的发展中的作用仍未得到充分研究.
研究的目的:
- 调查,铁和缺乏与新发性AFib的发生率之间的联系.
- 探索微量营养素状况与吸烟等风险因素之间与AFib发展有关的潜在相互作用.
主要方法:
- 一项前性队列研究,涉及5452名参与者.
- 测量血清,血清铁素 (铁) 和血的水平.
- 缺陷的定义:<70μg/L,费里丁<30μg/L,<0.85 mmol/L. 缺陷的定义是:<70 μg/L,费里丁<30 μg/L,<0.85 mmol/L. 缺陷的定义是:<70 μg/L,<30 μg/L,<0.85 mmol/L. 缺陷的定义是:<70 μg/L,<30 μg/L,<0.85 mmol/L.
- 随访时间平均为6.2年,以确定新出现的AFib事件.
主要成果:
- 缺陷的发生率: (21.2%),铁 (14.6%) 和 (66.0%).
- 在随访期间,136名参与者出现了新发性AFib (2.5%).
- 在多变量调整后,缺乏与非吸烟者的新发性AFib显著相关 (HR 1.69,p=0.020).
- 没有发现或铁缺乏与新发性AFib之间有显著的关联.
结论:
- 缺乏与新发性AFib的风险增加有关,特别是在不吸烟的人群中.
- 在这个队列中,和铁缺乏与AFib没有显著联系.
- 需要进一步的干预研究来评估优化状态对风险人群中AFib发病率的影响.
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