相关实验视频
Updated: Jul 19, 2025
08:36
In Vitro Assay to Study Tumor-macrophage Interaction
Published on: August 1, 2019
7.6K
针对巨细胞进行瘤治疗
Yixin Wang1,2,3, Allie Barrett1, Quanyin Hu4,5,6
1Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, WI, I 53705, Madison, U.S.A.
The AAPS journal
|August 17, 2023
概括
巨细胞是瘤的关键,M2类型促进生长. 针对这些与瘤相关的巨细胞 (TAMs) 提供了新的癌症治疗策略,包括复极化和生物模拟载体.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物医学工程 生物医学工程
背景情况:
- 巨细胞在瘤中丰富,并影响瘤的进展.
- 瘤相关巨细胞 (TAMs) 两极化 (M1与M2) 影响转移和治疗耐药性.
- M2巨细胞促进瘤生长和免疫逃避,而M1巨细胞可以攻击瘤细胞.
研究的目的:
- 审查巨细胞在瘤发育和转移中的作用.
- 总结一下巨细胞为中心的抗癌疗法的近期进展.
- 讨论在瘤学中向巨细胞的挑战和未来应用.
主要方法:
- 关于癌症中巨细胞生物学的文献综述.
- 针对瘤相关巨细胞的治疗策略的分析.
- 生物模拟载体的探索和CAR巨细胞工程.
主要成果:
- TAMs显著影响瘤进展,转移和治疗结果.
- 像TAM再极化,枯竭和信号封锁这样的策略显示出治疗的前景.
- 基于巨细胞的仿生载体增强了药物输送,降低了免疫性.
- 化学抗原受体 (CAR) 工程化的巨细胞提供向瘤细胞化.
结论:
- 通过向巨细胞来调节瘤免疫微环境,可以克服免疫抑制并增强抗瘤反应.
- 以巨为中心的疗法具有治疗固体,耐药和转移性瘤的潜力.
- 对基于巨细胞的策略的进一步研究将扩大癌症治疗选择.
更多相关视频
相关概念视频
02:17The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
01:27Tumor Immunotherapy
556
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
556
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K