替代疗法对男性性功能和阴性腺症状的影响 阴性腺症的男性
Karol M Pencina1, Thomas G Travison2, Glenn R Cunningham3
1Research Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
The Journal of clinical endocrinology and metabolism
|August 17, 2023
概括
在两年内,替代疗法 (TRT) 改善了男性的性活动,阴阴腺症状和性欲. 然而,TRT在这个研究群体中没有显著改善勃起功能.
科学领域:
- 内分泌学 在内分泌学.
- 男人的健康 男人的健康
- 临床试验 临床试验
背景情况:
- 替代疗法 (TRT) 治疗低阴性恋的长期疗效仍未得到充分评估.
- 很少有随机试验评估TRT在12个月以后对性功能和下腺症状的持续益处.
研究的目的:
- 评估TRT在改善性活动,阴茎下垂症症状,性欲和阴茎下垂症男性勃起功能方面的长期疗效.
- 在TRAVERSE试验中嵌入的性功能研究评估了这些影响,持续了24个月.
主要方法:
- 1161名男性 (45 - 80岁) 患有阴性腺和低性欲被随机分配给接受1.62%凝或安慰剂.
- 主要结局是性活动得分与基线的变化.
- 其次性结局包括下阴腺症状,勃起功能和性欲.
主要成果:
- 与安慰剂相比,TRT显著改善了性活动,效果在24个月内保持.
- 替代疗法也导致了下腺症状和性欲的改善.
- 与安慰剂相比,使用TRT没有观察到勃起功能的显著改善.
结论:
- 在中年和老年男性中进行两年TRT,这些男性患有阴道腺乱和性欲低下,可以增强性活动,阴道腺乱症状和性欲.
- 在这个队列中,TRT没有证明在改善勃起功能方面具有有效性.
- 这些发现有助于了解TRT对阴道下男性的长期益处和局限性.
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