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与种族和种族相关的人类微生物组变异早在3个月大时就出现了
Elizabeth K Mallott1,2,3, Alexandra R Sitarik4, Leslie D Leve5
1Vanderbilt Microbiome Innovation Center, Vanderbilt University, Nashville, Tennessee, United States of America.
PLoS biology
|August 17, 2023
概括
与种族和种族相关的肠道微生物组变异在儿童3个月后出现. 这种早期变异持续存在,影响成年人的健康,并导致健康差异.
科学领域:
- 人类微生物组研究研究
- 发育生物学是发展生物学.
- 在健康方面存在差异.
背景情况:
- 人类微生物组的组成与疾病发生率,流行率和死亡率有关.
- 众所周知,微生物组变异与美国的种族和种族有关.
- 这些种族和种族相关的微生物组差异在生命早期出现的具体年龄尚不清楚.
研究的目的:
- 确定儿童的种族和种族相关肠道微生物组变异的发病年龄.
- 调查这些变异在儿童时期的持续性.
- 确定影响这些关联的关键微生物种群和发育窗口.
主要方法:
- 分析了8项队列研究中729名儿童的肠道微生物组数据 (2756个样本).
- 利用机器学习模型来区分基于儿童微生物组的种族和民族类别.
- 对比在儿童中变化的细菌类与已知在成年人中变化的细菌类.
主要成果:
- 种族和种族相关的肠道微生物组变异在3个月后出现,并持续到童年.
- 机器学习使用童年微生物组数据准确区分种族和种族群体 (87%准确率).
- 预测儿童种族/族裔的税率对于预测成人种族/族裔也很重要.
结论:
- 在3个月或稍后的一个关键发育窗口被确定为建立种族和种族相关的微生物组模式.
- 社会和环境因素可能推动这些早期微生物群变异.
- 这些早期的微生物群差异可能会导致成人健康结果和健康差异.
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