费鲁酸通过调节微质细胞中的Nurr1表达来减少粉样β介导的神经炎症
Ali Moghimi-Khorasgani1,2, Farshad Homayouni Moghadam2, Mohammad Hossein Nasr-Esfahani2
1Department of Biology, Faculty of Science and Technology, ACECR Institute of Higher Education (Isfahan Branch), Isfahan, Iran.
PloS one
|August 17, 2023
概括
酸 (FA) 帮助称为微质细胞的脑免疫细胞过渡到非炎症状态. 通过增加Nurr1表达和减少炎症,FA促进愈合,为神经退行性疾病提供潜在的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 微质细胞 (MGCs) 是大脑巨细胞,对免疫防御至关重要.
- MGCs可以在平静状态和反应状态之间转换,及时的过渡有助于愈合.
- Nurr1的表达与大脑中的抗神经炎症作用有关.
研究的目的:
- 研究ferulic acid (FA) 在促进微质过渡中的作用.
- 探索FA通过抗炎和Nurr1诱导作用调节微质表型的潜力.
主要方法:
- 从小鼠中分离出初级微质细胞 (MGC).
- 细胞被用铁酸 (FA) 和β-粉胺 (Aβ) 处理.
- 基因表达 (Nurr1,IL-1β,IL-10) 通过qRT-PCR进行分析;细胞形态和NURR1-阳性细胞通过免疫染色和Image J软件进行评估.
主要成果:
- 治疗FA增加了Nurr1和IL-10,同时降低了MGC中的IL-1β.
- 在Aβ压力下,FA恢复了IL-10和Nurr1水平,并增加了分支指数 (RI).
- FA促进了从反应性 (形/棒状) 转向非炎症分支MGC形态的转变.
结论:
- 费鲁酸促进了Aβ-反应微质中的另一个恒常转变.
- 根据FA的NURR1依赖性抗炎作用表明它对神经炎症有治疗潜力.
- 通过增加在平静微质中的NURR1,FA可以作为预防性药物.
相关概念视频
03:03Amyloid Fibrils
9.6K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
9.6K
01:22Alzheimer's Disease: Treatment
213
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
213