没有脏范围蛋白尿的最小变化疾病的结果
Hyung Eun Son1,2, Giae Yun3, Eun-Jeong Kwon3
1Department of Internal Medicine, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Korea.
PloS one
|August 17, 2023
概括
最小变化疾病 (MCD) 的结果在患有和没有脏蛋白尿症 (NS) 的患者中是相似的. 对于所有成年MCD患者来说,仔细的管理是至关重要的,无论最初的蛋白尿水平如何.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内部医学 内部医学
- 病理学 病理学 病理学
背景情况:
- 最小变化疾病 (MCD) 通常表现为和脏范围蛋白尿 (NS).
- 没有NS的MCD的长期预后尚未明确.
- 了解非脏性MCD的结果对于患者管理至关重要.
研究的目的:
- 为了比较成人初级MCD患者的临床病理特征和结局,有或没有初始NS.
- 在两组中调查NS进展的频率和治疗反应.
- 为了确定最初的蛋白尿水平是否会影响MCD的长期结局.
主要方法:
- 79名通过脏活检诊断的成人初级MCD患者的回顾性审查.
- 在诊断时具有和没有NS的患者之间的临床和病理数据的比较.
- 在随访期间评估蛋白尿症爆发,治疗反应,复发率和结局.
主要成果:
- 与NS组 (59名患者) 相比,非NS组 (20名患者) 在诊断时急性损伤 (AKI) 的发生率明显较低.
- 在两组中,类固醇治疗的反应都很高 (非NS的100%,NS的92.3%).
- 两组之间没有观察到复发频率,事件,末期病或死亡率的显著差异.
结论:
- 成年MCD患者有或没有初始NS表现出类似的长期结局.
- 最初的蛋白尿水平似乎不是MCD预后的主要决定因素.
- 所有成年MCD患者都需要仔细管理和监测,无论最初的蛋白尿状况如何.
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