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通过使用可解释机器学习来释PROTAC诱导的降解准的全基因组未研究的蛋白质

Li Xie1, Lei Xie1,2,3

  • 1Department of Computer Science, Hunter College, The City University of New York, New York City, New York, United States of America.

PLoS computational biology
|August 17, 2023
PubMed
概括

化向的嵌合体 (PROTACs) 可以降解向蛋白质. 一个新的机器学习模型PrePROTAC预测了全基因组的PROTAC目标,确定了600多个新型候选人和药物开发的关键残留物.

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