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Updated: Jul 19, 2025

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method
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Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method

Published on: May 2, 2025

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在蛋白相互作用选中发现了DONSON在复制启动中的作用

Yang Lim1, Lukas Tamayo-Orrego2, Ernst Schmid1

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA 02115, USA.

Science (New York, N.Y.)
|August 17, 2023
PubMed
概括

通过组装CDC45-MCM2-7-GINS (CMG) 螺旋酶,DONSON蛋白对于真核DNA复制的启动至关重要. 突变导致小脑化, 凸显了它在人类发展中的作用.

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