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Identification of Kinase-substrate Pairs Using High Throughput Screening
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一个生物物理框架,用于双重作用的激酶

Chansik Kim1,2, Hannes Ludewig1,2, Adelajda Hadzipasic1,2

  • 1Department of Biochemistry, Brandeis University, Waltham, MA 02454.

Proceedings of the National Academy of Sciences of the United States of America
|August 17, 2023
PubMed
概括

通过同时针对orthosteric和allosteric位点的双重药物激酶,提供了一种协同方法来克服药物耐药性. 这一策略增强了药物的有效性,并减少了对奥罗拉A激酶和阿贝尔森激酶抑制所需的剂量.

关键词:
形态平衡的形态平衡.合作性是一种合作性.双重麻醉是什么意思激酶激酶的作用是什么

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