间歇性肺异常的长期随访:对随访策略和风险值的影响
Sohee Park1, Jooae Choe1, Hye Jeon Hwang1
1Department of Radiology and Research Institute of Radiology.
American journal of respiratory and critical care medicine
|August 17, 2023
概括
每3年进行一次随访CT扫描可能适用于监测间歇性肺异常 (ILA) 的进展. 患有纤维性ILA和蜂状细胞的高风险个体可能会从更频繁的成像中受益.
科学领域:
- 肺部病理学 肺部病理学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 间歇性肺部异常 (ILA) 是胸部CT扫描中的发现,通常在接受肺癌查的个体中发现.
- 随访成像检测ILA进展及其潜在过渡到通常的间歇性肺炎 (UIP) 的最佳频率仍未确定.
- 早期发现ILA进展对于及时干预和改善患者结果至关重要.
研究的目的:
- 为了确定间歇性肺异常 (ILA) 的最佳后续计算机断层扫描 (CT) 间隔.
- 确定CT成像值,表明ILA进展和不良结果.
- 评估与ILA进展和常见间歇性肺炎 (UIP) 的发展相关的风险因素.
主要方法:
- 对305名50岁及以上的查参与者的胸部CT扫描进行了回顾性分析.
- 深度学习算法用于定量评估ILA程度.
- 考克斯回归分析确定了ILA进展和UIP进展的风险因素.
主要成果:
- 在239名患有ILA的参与者中,80.5%的患者在平均11.3年的随访期间表现出进展.
- 在17.3%的参与者中,UIP的进展发生,平均时间为11.8年.
- 纤维化ILA程度 (HR 1.12) 和蜂是进展和不良结果的独立风险因素,影响了10年生存率.
结论:
- 在大多数人中,为监测ILA进展,3年的随访CT间隔似乎是合适的.
- 患有显著纤维化ILA程度和蜂病的患者是高风险群体.
- 对于高风险个体,建议缩短随访间隔,以监测进展和潜在的不良事件.
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