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Updated: Jul 19, 2025

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
型肝炎病毒在产前传播的危险因素
Mona Prasad1, George R Saade, Rebecca G Clifton
1Departments of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio, University of Texas Medical Branch, Galveston, Texas, Brown University, Providence, Rhode Island, MetroHealth Medical Center-Case Western Reserve University, Cleveland, Ohio, University of Alabama at Birmingham, Birmingham, Alabama, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, University of Utah Health Sciences Center, Salt Lake City, Utah, Columbia University, New York, New York, Boston Medical Center, Boston, Massachusetts, University of Pittsburgh, Pittsburgh, Pennsylvania, Duke University, Durham, North Carolina, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, University of Texas Health Science Center at Houston-Children's Memorial Hermann Hospital, Houston, Texas, Northwestern University, Chicago, Illinois, Stanford University, Stanford, California, University of Texas Southwestern Medical Center, Dallas, Texas, University of Pennsylvania, Philadelphia, Pennsylvania, University of Florida Center for HIV/AIDS Research, Education and Service, Jacksonville, Florida, San Juan Hospital, San Juan, Puerto Rico, Children's Diagnostic and Treatment Center, Fort Lauderdale, Florida, Jacobi Medical Center, Bronx, New York, University of Southern California, Los Angeles, California, SUNY Stony Brook, Stony Brook, New York, and Washington University in St. Louis, St Louis, Missouri; and the George Washington University Biostatistics Center, Washington, DC; and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
型肝炎病毒 (HCV) 周产期传播发生在6.0%的病例中,主要发生在病毒性个体中. 高病毒载量和产前出血显著增加了传播风险.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
背景情况:
- 型肝炎病毒 (HCV) 感染存在从母亲传给婴儿的孕期传播风险.
- 了解传播动态和风险因素对于预防策略至关重要.
研究的目的:
- 为了估计围产期型肝炎病毒传播率.
- 确定与母婴HCV传播相关的关键风险因素.
- 为了确定是否存在围产期HCV传播的病毒性值.
主要方法:
- 一项前性的多中心观察研究涉及查孕妇的HCV感染.
- 在整个怀孕期间,对HCV阳性参与者进行了跟踪,并对他们的婴儿进行了传播监测.
- 围产期传播是由随访时婴儿的阳性HCVRNA或抗体测试定义的.
主要成果:
- 总的 HCV 周产期传播率为 6.0%.
- 传染仅在病毒性个体中观察到,其中的传播率为8.0%.
- 超过106 IU/mL的HCVRNA水平和产前阴道出血是传播的重要风险因素.
结论:
- 周产期HCV传播仅限于具有可检测的病毒性血症的母亲.
- 高母体病毒载量和产前出血是母婴HCV传播的重要危险因素.
- 在这项研究中,无法确定围产期传播的确切病毒性值.
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