酒精和睡眠相关特征之间的关系:多基因风险评分和门德尔随机化分析的结果
Subhajit Chakravorty1, Rachel L Kember1, Diego R Mazzotti2
1Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA 19104, USA; Perelman School of Medicine, Philadelphia, PA 19104, USA.
Drug and alcohol dependence
|August 17, 2023
概括
对失眠的遗传倾向和睡眠时间缩短增加了酒精使用障碍 (AUD) 的风险. 睡眠异常对AUD发育有因果影响,突出显示睡眠与酒精消费之间存在重大联系.
科学领域:
- 遗传学 是一个遗传学.
- 睡眠医学 睡眠医学
- 精神病学是一个精神病学.
背景情况:
- 失眠和睡眠时间异常很普遍,并与各种健康状况有关.
- 酒精使用障碍 (AUD) 构成了重大的公共卫生挑战.
- 了解睡眠和酒精使用之间的相互作用对于开发有效干预措施至关重要.
研究的目的:
- 调查失眠遗传风险和睡眠时间与AUD和酒精消费之间的关联.
- 用门德尔随机化评估睡眠特征和与酒精有关的疾病之间的因果关系.
- 探索睡眠障碍的遗传风险与AUD之间的性效应.
主要方法:
- 利用来自百万退伍军人计划的个体级表型和基因型数据.
- 来自大型全基因组关联研究 (GWAS) 的失眠和睡眠时间的计算多基因风险评分 (PRS).
- 进行双向双样本的门德尔随机化 (MR) 分析,以评估因果关系.
主要成果:
- 失眠PRS与AUD积极相关,与酒精消费负相关 (AUDIT-C).
- 睡眠时间较短的PRS与酒精消费有积极的关联 (AUDIT-C).
- 核磁共振分析证实了失眠对AUD和睡眠时间缩短对AUD风险的因果关系,失眠的异质性显著.
结论:
- 不眠症的遗传风险是 AUD 的 pleiotropic.
- 睡眠连续性的异常因果关系地影响了AUD的发展.
- 这些发现强调了在AUD预防和治疗策略中解决睡眠障碍的重要性.
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