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淋巴细胞免疫类型和MMP-9的度在马的转化和排泄物中

Pavla Hamouzová¹, Olga Dobešová², Kristína Řeháková³

¹Department of Physiology, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, Palackého 1946/1, 612 42 Brno, Czech Republic.

Veterinary immunology and immunopathology

|August 17, 2023

概括

这项研究分析了马类腹排泄中的淋巴细胞亚群,发现CD4+细胞是最常见的. 矩阵金属蛋白酶-9 (MMP-9) 水平在排泄物中较高,与中性粒细胞和总蛋白相关.

科学领域:

兽医免疫学兽医免疫学
马类内部医学马类内部医学
临床病理学临床病理学

背景情况:

马的腹腔液是具有挑战性的诊断.
了解淋巴细胞亚群和炎症标志物对于诊断和预后至关重要.

研究的目的:

为了表征马类腹膜转化和排泄物中的淋巴细胞亚群.
评估这些液中总蛋白 (TP) 和矩阵金属蛋白酶-9 (MMP-9) 的度.
将这些发现与细胞学评估和临床结果相关联.

主要方法:

对腹过体 (n=12) 和外体 (n=6) 的分析.
通过ELISA测量总核细胞计数 (TNCC),总蛋白质 (TP) 和MMP-9.
流细胞计检测CD3,CD4,CD8和CD21阳性淋巴细胞.
常规细胞学评估.

主要成果:

与转化体相比,外皮体显示出较高的中性粒细胞百分比和MMP-9水平.
转化剂的巨细胞和淋巴细胞百分比较高.
CD4+淋巴细胞是最丰富的亚群;CD21+淋巴细胞是最不常见的.
MMP-9与中性粒细胞,TP和TNCC正相关.
在安乐死马中观察到更高的MMP-9水平.

结论:

淋巴细胞亚种群分析提供了对马类腹腔液的洞察力.
MMP-9是马出血中的潜在炎症标志物,与严重程度相关.
需要进一步研究重复腹腔切割,以证实MMP-9的预后价值.

关键词:

腹腔位是指腹腔位.乙型淋巴细胞B型淋巴细胞埃索诺菲尔细胞是什么意思腹腔周围的液体幸存下来是为了生存.的T淋巴细胞.在Tc淋巴细胞中.这类淋巴细胞是Th淋巴细胞.

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