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影响肺癌的瘤微环境中的非免疫细胞成分免疫疗法

Jingtao Zhang¹, Shuai Liu², Xiubao Chen³

¹College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250014, China.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

|August 17, 2023

概括

了解肺癌复杂的免疫网络对于改善免疫疗法至关重要. 本综述指导了针对瘤微环境 (TME) 的策略,以获得更好的治疗结果.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症研究癌症研究

背景情况:

肺癌 (LC) 仍然是全球癌症死亡的主要原因.
免疫疗法改变了癌症治疗,改善了反应和生存率.
需要进一步了解LC复杂的免疫微环境,以提高免疫治疗的疗效.

研究的目的:

审查肺癌瘤微环境 (TME) 中复杂的免疫网络.
阐明肺癌细胞使用的免疫逃避机制.
为开发针对LC的新型多向免疫疗法策略提供指导.

主要方法:

对肺癌免疫学和免疫疗法当前研究的文献综述.
对LC中的瘤相关抗原 (TAA) 和瘤特异抗原 (TSA) 的分析.
检查免疫逃生机制,包括免疫抑制细胞,细胞因子和TME的作用.

主要成果:

液结细胞表达TAA和TSA,启动抗瘤免疫反应.
瘤细胞采用免疫逃生机制,产生一种免疫抑制的TME.
诸如细胞因子,微生物组,纤维细胞和内皮细胞等因素有助于免疫逃避.

结论:

对LC免疫网络的全面了解对于促进免疫疗法的发展至关重要.
将免疫疗法与其他治疗方法结合起来,可以产生协同效应.
针对TME提供了一个有前途的策略,以提高LC免疫疗法的疗效.

关键词:

收养T细胞疗法采用T细胞疗法国际投资机构 (ICI) 是国际投资机构 (ICI) 的一个组成部分.免疫治疗是一种免疫疗法.LC LC LC LC LC LC LC LC LC 在此之前,TME的这是瘤疫苗.

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