吸入生物可访问性和PM结合有机成分的风险评估:组件物理化学特性,PM特性和来源的副作用
Xinyi Liu1, Xiaoning Wang1, Qianqian Xue1
1The State Environmental Protection Key Laboratory of Urban Air Particulate Matter Pollution Prevention and Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China.
Journal of hazardous materials
|August 17, 2023
概括
这项研究评估了中国大城市颗粒物 (PM) 中有机污染物的吸入生物可访问性. 污染物的生物可访问性因季节和来源而异,较少的疏水性有机物更容易获得,影响健康风险评估.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 大气化学 大气化学
背景情况:
- 吸入生物可访问性和有机成分在大气颗粒物 (PM) 中的沉积对于健康风险评估至关重要.
- 了解人类对PAH,PAE,PCB和OPFR等污染物的暴露至关重要.
研究的目的:
- 为了评估各种有机污染物的体外吸入生物可访问性,从一个中国大城市的尺寸解析的PM中.
- 调查颗粒大小,碳分数和排放源对有机污染物生物可访问性的影响.
- 为了估计与PM成分相关的健康风险 (ILCR和HQ),考虑生物可访问性和沉积.
主要方法:
- 在体外吸入PAH,PAE,PCB和OPFR的生物可访问性评估在尺寸解析的PM中.
- 在加热和非加热期间收集的PM的分析.
- 生物可访问性,物理化学性质 (logKow,碳分数) 和排放源之间的相关性分析.
- 增量终身癌症风险 (ILCR) 和危险系数 (HQ) 的估计.
主要成果:
- 在加热 (0.2%77.8%) 和不加热 (0.7%94.2%) 期间,生物可访问性差异很大.
- 较少疏水的有机物表现出更高的生物可访问性.
- 高碳分数抑制了中等logKow有机物 (>0.65微米) 的生物可访问性.
- 煤炭/生物质燃烧 (加热) 和交通排放 (非加热) 与生物可访问性有负相关性.
- 二次颗粒还降低了中等物质的生物可访问性.
- 估计的HQ和ILCR处于可接受的范围内,其中BaP和DEHP是主要贡献者.
结论:
- 季节性变化和排放源对PM中的有机污染物的吸入生物可访问性产生重大影响.
- 颗粒的特性,如疏水性和碳含量,调节了污染物的生物可用性.
- 将生物可访问性和沉积数据纳入其中,可以完善大气中的PM的健康风险评估.
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