臭氧暴露与精子质量指标相关:精子端粒长度作为潜在的调解因素
Zhong-Hua Lu1, Bin Sun2, Yi-Xin Wang3
1State Key Laboratory of Vaccines for Infectious Diseases，Xiang An Biomedicine Laboratory，State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics，National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Public Health, Xiamen University, Xiamen, Fujian, China.
Journal of hazardous materials
|August 17, 2023
概括
臭氧 (O3) 污染可能对精子质量产生负面影响,包括精子端粒长度 (STL). 这项研究表明,臭氧暴露会影响精子参数,可能由STL的变化介导.
科学领域:
- 环境健康 环境健康
- 生殖生物学 生殖生物学
- 毒理学 毒理学 毒理学
背景情况:
- 关于臭氧 (O3) 暴露与人类精液质量之间存在联系的证据有限且相互矛盾.
- 这种关联的潜在机制在很大程度上仍然不清楚.
研究的目的:
- 调查环境臭氧 (O3) 暴露与精子质量参数之间的关联.
- 探索精子线粒体DNA拷贝数 (mtDNAcn) 和精子端粒长度 (STL) 在这种关系中的介导作用.
主要方法:
- 分析了来自1068名潜在精子捐赠者的5002个重复精液样本.
- 评估大约90天内环境臭氧 (O3) 暴露水平.
- 统计分析以确定mtDNAcn和STL的关联和调解效应.
主要成果:
- 增加的臭氧 (O3) 暴露与精子端粒长度 (STL),精子度,总计数,总运动精子数和精子体积的减少相关.
- 臭氧 (O3) 暴露与增加的总和渐进的精子运动性有关.
- 当臭氧 (O3) 暴露发生在精子生成早期阶段 (I和II) 时,相关性更强.
- 精子端粒长度 (STL) 部分介导了臭氧 (O3) 暴露与精子度 (9%) 和精子数量 (8%) 之间的关系.
结论:
- 臭氧 (O3) 污染可能会对精子端粒长度 (STL) 产生不利影响.
- 臭氧 (O3) 暴露可能导致精液质量降低,STL扮演中介角色.
- 这些发现突出了与环境臭氧 (O3) 暴露相关的潜在生殖健康风险.
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