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Updated: Jul 19, 2025

A Protocol for Functional Assessment of Whole-Protein Saturation Mutagenesis Libraries Utilizing High-Throughput Sequencing
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学习蛋白质健身景观,使用来自多个来源的深度突变扫描数据

Lin Chen1, Zehong Zhang1, Zhenghao Li2

  • 1Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.

Cell systems
|August 17, 2023
PubMed
概括

本研究引入了一种多蛋白培训方案,通过利用现有数据更准确地绘制蛋白质健身景观来改进机器学习辅助定向进化 (MLDE). 这些发现突出了MLDE的潜在陷,并建议更好的蛋白质工程方法.

关键词:
指导进化是指导进化的.经验表现效应的影响.健身景观 健身景观机器学习是机器学习.多任务学习是多任务学习.蛋白质变异效应影响蛋白质变异效应

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相关概念视频

Spontaneous and Induced Mutations01:30

Spontaneous and Induced Mutations

Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
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