相关实验视频

Updated: Jul 19, 2025

Preparation of Acute Spinal Cord Slices for Whole-cell Patch-clamp Recording in Substantia Gelatinosa Neurons

Preparation of Acute Spinal Cord Slices for Whole-cell Patch-clamp Recording in Substantia Gelatinosa Neurons

Published on: January 18, 2019

在慢性脊髓损伤下,体感皮质的兴奋性增加和GABAergic水平降低

Elena Alonso-Calviño¹, Elena Fernández-López¹, Marta Zaforas¹

¹Experimental Neurophysiology Group, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain; Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Toledo, Spain.

Experimental neurology

|August 17, 2023

概括

脊髓损伤导致皮层重组,但程度因损伤类型而异. 这种大脑可塑性涉及皮层刺激性增加和GABA传输的变化,尽管并非所有人都表现出这些影响.

科学领域:

神经科学是一个神经科学.
脊髓损伤研究脊髓损伤研究
神经可塑性神经可塑性

背景情况:

脊髓损伤 (SCI) 可以损害体感路径,导致大脑皮层重组.
目前尚不清楚SCI严重程度是否决定了这种皮质重组的程度或性质.

研究的目的:

调查体感皮质皮质的皮质重组是否取决于脊髓损伤的类型.
探索损伤严重程度,皮层重组和皮层刺激性之间的关系.

主要方法:

纵向电生理学记录的体感唤起的反应在后肢和前肢皮质的动物与全切口或伤性SCI.
在受伤之前和每周一次,在受伤后最多4周进行记录.
在皮层层中分析GABA标志物GAD67水平.

主要成果:

皮层重组模式在完全切割 (更双边) 和伤性 (更单边) SCI模型之间有所不同.
大约80%的受试者在完全切割后,在脱离和完整的皮质中表现出类似的体感触发反应增加.
在患有SCI的动物中观察到皮层刺激性增加,由触发的上升状态表明.
降低的GAD67水平与增加的体感官唤起反应相关,但在未受影响的个体中没有.

结论:

在SCI之后的皮层重组取决于特定类型的损伤,并受到皮层电路的强烈影响.
在GABAergic传输的变化可能是皮层重组和SCI后的高兴度的基础.
皮层重组不是SCI的普遍结果,有些人仍然不受影响.

关键词:

皮层过度刺激性皮层过度刺激性皮层重组是皮层的重组.对于GABA来说,这是一个很好的选择.通过感官唤起的反应.慢波活动的缓慢波活动.人体感官皮层体感官皮层.脊髓损伤导致的脊髓损伤触发的上升状态表示.

更多相关视频

Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats

Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats

Published on: April 4, 2012

Measuring Spinal Presynaptic Inhibition in Mice By Dorsal Root Potential Recording In Vivo

Measuring Spinal Presynaptic Inhibition in Mice By Dorsal Root Potential Recording In Vivo

Published on: March 29, 2014

相关概念视频

Somatosensation

Somatosensation

The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.

Overview of Somatic Sensory Pathways

Overview of Somatic Sensory Pathways

Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...