使用核磁共振量化的肌酸和肌酸氨酸:一种方法验证研究和循环肌酸与脏移植接受者的疲劳之间的临床关联
Adrian Post1, Erwin Garcia2, Irina Shalaurova2
1Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, the Netherlands.
概括
肌酸稳定性受损可能会导致移植接受者 (KTR) 疲劳. 较高的肌酸水平与KTR中较少的疲劳和更好的动机有关,这表明肌酸补充可能有所帮助.
科学领域:
- 生物化学 生物化学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 医学诊断 医学诊断 医学诊断
背景情况:
- 疲劳是移植接受者 (KTR) 的一个常见问题.
- 肌酸平衡受损是KTR中疲劳的潜在原因.
- 开发了一种新的NMR测定方法来测量肌酸和肌素.
研究的目的:
- 开发和验证用于同时测量肌酸和肌酸的高通量NMR试验.
- 确定KTR中的血和估计的肌内肌酸度.
- 探索KTR中肌酸水平的决定因素及其与疲劳的关联.
主要方法:
- 开发并验证了一种核磁共振 (NMR) 测定肌酸和肌素的方法.
- 在618KTR中测量了血肌酸和肌素.
- 使用检查清单个人力量评估疲劳,并使用线性混合效应模型分析与肌酸参数的关联.
主要成果:
- 核磁共振试验显示出良好的灵敏度,精度和线性.
- 在KTR中 (平均年龄56岁,62%的男性,eGFR54),血肌酸是27 [19-39] μmol/L,估计肌内肌酸是27 ± 7 mmol/kg.
- 较高的血和估计的肌内肌酸度独立地与较低的疲劳得分和更好的动机相关.
结论:
- 一种经过验证的NMR方法可以有效量化循环中的肌酸和肌素.
- 研究结果表明,优化肌酸状态可能有助于缓解KTR中的疲劳.
- 对治疗KTR疲劳的肌酸补充剂的进一步研究是有必要的.
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