新型奇托/γ-/碳量子点水凝纳米载体,用于向药物输送
Mohammad Hossein Karami1, Mehrab Pourmadadi2, Majid Abdouss1
1Department of Chemistry, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.
International journal of biological macromolecules
|August 17, 2023
概括
一种新的基托基水凝纳米载体加载黄素有效治疗癌症. 这种先进的药物输送系统显示了高药物负载和pH敏感释放,用于向瘤治疗.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 黄素 (CUR) 是一种天然的抗瘤剂,由于溶解性差和半衰期短,有效性有限.
- 需要有效的药物输送系统来克服癌症治疗的这些局限性.
研究的目的:
- 开发一种新的水凝纳米载体,以改善黄素的输送.
- 评估纳米载体的物理化学性质,药物负载,释放动力学和抗癌疗效.
主要方法:
- 使用W/O/W双纳米乳液方法制造一种素 (CS) / (γ-Al2O3) /碳量子点 (CQD) 水凝纳米载体.
- 使用动态光散射 (DLS),场辐射扫描电子显微镜 (FE-SEM),里埃变形红外光谱 (FT-IR) 和X射线衍射 (XRD) 的表征.
- 在乳腺癌细胞中评估药物负载,捕获效率,pH敏感药物释放,细胞毒性和亡诱导.
主要成果:
- 该CS/γAl2O3/CQDs纳米载体表现出稳定的准球形结构 (227纳米大小,-37.8mV泽塔电位).
- 库尔库明的药物负载 (48%) 和捕获效率 (86%) 高.
- 该纳米载体证明了受控的,pH敏感的黄素释放,在酸性条件下释放的增强,并诱导了显著的乳腺癌细胞亡.
结论:
- 开发的CS/γAl2O3/CQDs纳米载体是一种稳定有效的黄素输送系统.
- 纳米载体显示承诺作为一种新的纳米系统,用于增强瘤治疗,由于其受控释放和诱导亡的特性.
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