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Updated: Jul 19, 2025

A New Straightforward Method for Lipophilicity logP Measurement using 19F NMR Spectroscopy
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A New Straightforward Method for Lipophilicity logP Measurement using 19F NMR Spectroscopy

Published on: January 30, 2019

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一种强大,可行的,节省资源的基于HPLC的logP方法,应用于常见药物

Ana L Coutinho1, Rodrigo Cristofoletti2, Fang Wu3

  • 1Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, United States.

International journal of pharmaceutics
|August 17, 2023
PubMed
概括

这项研究提出了一种使用HPLC测量药物脂友性 (logP) 的新有效方法. 这种方法为药物开发的计算预测提供了一个可靠的替代方案.

关键词:
脂友性 脂友性 脂友性分割系数的分配系数预制 预制 预制反相高性能液态染色学 逆相高性能液态染色学可溶性 溶解度 可溶性

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