儿科移植:在6岁以下和6岁以上的捐赠者身上的结果
Simone Lysakowski1, Clotilde Druck Garcia1, Roberta Weisheimer Rohde2
1Universidade Federal de Ciências da Saúde de Porto Alegre, Irmandade Santa Casa de Misericórdia de Porto Alegre, Programa de Pós-Graduação em Pediatria, Porto Alegre, RS, Brazil.
Jornal de pediatria
|August 17, 2023
概括
从较年轻的捐赠者 (≤6岁) 进行的儿科已故捐赠者移植显示了与较老的捐赠者相比的移植存活率. 然而,年轻的捐赠者在移植后的一年后,导致功能略有下降.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 儿科手术 儿科手术
- 移植免疫学 移植免疫学
背景情况:
- 儿童移植 (PKT) 的缺乏需要使用更年轻,更小的捐赠者.
- 这种做法引起了人们的担忧,尽管急需进行儿科已故捐赠者移植 (pDDKT).
研究的目的:
- 分析儿科已故捐赠者移植 (pDDKTs) 在手术后第一年内的结果.
- 根据捐赠者的年龄来分层结果.
主要方法:
- 在2013年1月至2018年1月期间进行的pDDKT的回顾性队列研究.
- 捐赠者被分为两个组:≤6岁 (组1) 和>6岁 (组2).
主要成果:
- 分析了143种pDDKT,包括第1组的51种和第2组的92种.
- 一年后的移植存活率在各组之间是相似的 (p=0.95),血管血栓形成是移植损失的主要原因.
- 需要干预的动脉狭窄在第一组更频繁 (7.8%对2.2%).
- 12个月后的淋巴细胞过率 (GFR) 在第二组 (79.3毫升/分钟/1.73m2) 与第一组 (69.7毫升/分钟/1.73m2;p=0.033) 相比,更高.
结论:
- 从较年轻的捐赠者 (≤6岁) 进行儿科已故捐赠者的移植是可行的.
- 移植的存活率与老年捐赠者的存活率相当.
- 精心的外科专业知识对于成功的pDDKT结果至关重要,特别是在年轻的捐赠者身上.
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