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在仿真抗原受体T细胞疗法中细胞因子信号传递

Yuki Kagoya1

  • 1Division of Tumor Immunology, Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan.

International immunology
|August 17, 2023
PubMed
概括

化学抗原受体 (CAR) -T细胞疗法对血液癌症有希望,但缺乏耐用性. 调节细胞因子信号的基因工程策略可以增强CAR-T细胞功能并减轻毒性,以改善癌症治疗.

关键词:
收养免疫疗法采用免疫疗法.细胞因子释放综合征 细胞因子释放综合征神经毒性的作用.

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Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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