条状直接和间接途径神经元的相应激活和沉默支持行为编码行为
Christophe Varin1, Amandine Cornil1, Delphine Houtteman1
1Université Libre de Bruxelles (ULB), ULB Neuroscience Institute, Neurophysiology Laboratory, Brussels, Belgium.
Nature communications
|August 17, 2023
概括
基底腺节是基底腺节.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 行为科学 行为科学
背景情况:
- 基底,特别是背上条纹体,对于运动控制和行动选择至关重要.
- 关于直接和间接路径在运动控制中的作用,存在不同的发现.
- 了解这些途径是解读行为调节的关键.
研究的目的:
- 为了研究背上条纹体的直接和间接途径如何编码自发探索期间的行为.
- 澄清这些通路在运动控制中的不同功能作用.
主要方法:
- 利用成像来监测直接和间接途径中的神经元活动.
- 采用监督学习算法来解码来自神经元组合的行为表征.
- 在动物的自律开场探索过程中观察到的神经元活动.
主要成果:
- 直接和间接通路表现出不同的神经元调特性.
- 直接通路神经元通过激活编码行为.
- 间接通路神经元通过特定的沉默编码行为,这种沉默在几周内保持稳定.
结论:
- 直接和间接的路径提供了一个互补的行为编码.
- 直接路径激活促进了可访问的行为,而间接路径沉默抑制了竞争行动.
- 这种互补的模型协调了关于条状运动控制的相互矛盾的先前发现.
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