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Updated: Jul 19, 2025

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皮鲁酸烯酸透症是持续性白血病干细胞中的一个可向的脆弱性

Kevin M Rattigan1, Zuzana Brabcova1, Daniele Sarnello1

  • 1Wolfson Wohl Cancer Research Centre; Institute of Cancer Sciences, University of Glasgow, Glasgow, G61 1QH, UK.

Nature communications
|August 17, 2023
PubMed
概括

慢性骨髓性白血病 (CML) 中的白血病干细胞表现出持续的代谢变化,特别是增加的酸盐厌血症,即使在TKI治疗后. 通过MPC抑制剂向这种代谢脆弱性显示出对Imatinib耐药CML的承诺.

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